[Effect of gufuhuo decoction on local apoptosis of steroid-induced necrosis of femoral head].
Zhongguo Zhong Yao Za Zhi
; 30(23): 1848-51, 2005 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-16499025
ABSTRACT
OBJECTIVE:
To observe the bone specimen of SANFH (steroid-induced avascular necrosis of femoral head) and the effect of Gufuhuo decoction on local apoptosis of SANFH.METHOD:
Model rabbits of necrosis of femoral head, made by intragluteal injection with prednisone acetate, were killed after 6 weeks to study the apoptosis by means of TUNEL.RESULT:
A great number of faded osteocytes and osteoblasts existed in specimen of SANFH. There was significant difference in apoptosis indexes between model and control group, Gufuhuo decoction and Xianlinggubao group (P < 0.05).CONCLUSION:
In the course of SANFH, the necrosis results from the interaction of apoptosis and necrosis of steroid-induced osteocytes and osteoblasts. Gufuhuo decoction has some effects on improving apoptosis and necrosis of SANFH.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Plantas Medicinales
/
Medicamentos Herbarios Chinos
/
Apoptosis
/
Necrosis de la Cabeza Femoral
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2005
Tipo del documento:
Article
País de afiliación:
China