Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers.
Eur Neuropsychopharmacol
; 16(7): 512-20, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-16545549
ABSTRACT
RATIONALE Nicotine increases dopamine (DA) release but its role in nicotine dependence remains unclear. OBJECTIVE:
To assess the role of DA in nicotine craving and self-administration using acute phenylalanine/tyrosine depletion (APTD).METHODS:
Fifteen nicotine-dependent men ingested, a minimum of 3days apart, a nutritionally balanced amino acid (AA) mixture (BAL), a mixture deficient in the catecholamine precursors, phenylalanine and tyrosine, and APTD followed by the immediate DA precursor, L-DOPA. Beginning 3h after ingestion of the AA mixture, subjects smoked 4 cigarettes. Craving, mood, and other aspects of subjective state were assessed with self-report scales. Smoking puff topography was measured with a computerized flowmeter.RESULTS:
APTD did not change smoking puff topography, cigarette craving, or subjective effects of smoking.CONCLUSIONS:
The findings suggest that in nicotine-dependent smokers craving for cigarettes, subjective effects of nicotine, and the self-administration of freely available cigarettes are largely unrelated to acute changes in DA neurotransmission.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_sustancias_psicoativas
Asunto principal:
Tabaquismo
/
Dopamina
/
Dieta con Restricción de Proteínas
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur Neuropsychopharmacol
Asunto de la revista:
PSICOFARMACOLOGIA
Año:
2006
Tipo del documento:
Article