Control of cell migration in the zebrafish lateral line: implication of the gene "tumour-associated calcium signal transducer," tacstd.
Dev Dyn
; 235(6): 1578-88, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16552761
ABSTRACT
The sensory organs of the zebrafish lateral-line system (neuromasts) originate from migrating primordia that move along precise pathways. The posterior primordium, which deposits the neuromasts on the body and tail of the embryo, migrates along the horizontal myoseptum from the otic region to the tip of the tail. This migration is controlled by the chemokine SDF1, which is expressed along the prospective pathway, and by its receptor CXCR4, which is expressed by the migrating cells. In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins. Inactivation of the zebrafish tacstd gene results in a decrease in proneuromast deposition, suggesting that tacstd is required for the deposition process.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Glicoproteínas de Membrana
/
Movimiento Celular
/
Señalización del Calcio
/
Proteínas de Pez Cebra
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Dyn
Asunto de la revista:
ANATOMIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Chile