The effects of fluoxetine and its complexes with glycerrhizic acid on behavior in rats and brain monoamine levels.
Neurosci Behav Physiol
; 36(4): 329-33, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16583158
ABSTRACT
The effects of the serotonin reuptake inhibitor fluoxetine (FL) and its complexes with glycyrrhizic acid (GA) in molar ratios of 11 (FLG-1) and 41 (FLG-4) on the behavior of adult rats were studied in an elevated cross maze, with measurement of brain monoamine and monamine metabolite levels. Agents were given via the intragastric route using a cannula at a dose of 25 mg/kg 1 h before testing. FL increased anxiety in the rats and decreased their movement activity; FLG-1 and FLG-4 had no effect on behavior. None of the agents affected brain serotonin content, though all decreased the levels of its metabolite 5-hydroxyindoleacetic acid in the hypothalamus, FLG-4 also decreasing this in the cortex. Noradrenaline levels in the hypothalamus were increased after FLG-1 and FLG-4. In the striatum, FL increased the levels of dopamine and its metabolite dihydroxyphenylacetic acid but had no effect on the level of transmitter catabolism. Unlike FL, FLG-1 activated dopamine metabolism in the striatum. Overall, use of FL complexed with GA significantly modified its behavioral effects, which appears to be associated with the effects of FL and its complexes on the function of the monoaminergic systems involved in controlling behavior.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
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Encéfalo
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Monoaminas Biogénicas
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Fluoxetina
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Inhibidores Selectivos de la Recaptación de Serotonina
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Ácido Glicirrínico
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Antiinfecciosos
Límite:
Animals
Idioma:
En
Revista:
Neurosci Behav Physiol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Rusia