Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 101(5): 614-9, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16632273
ABSTRACT
OBJECTIVE:
To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton. STUDYDESIGN:
The histology and immunohistochemistry of 4 PSOFs, 6 COFs, and 7 PMs was studied. Antibodies included EMA, cytokeratins, smooth muscle actin (SMA), desmin, vimentin, CD34, CD10, S-100 protein, and glial fibrillary acidic protein (GFAP).RESULTS:
All PSOFs showed multiple round ossicles homogeneously distributed within a fibroblastic stroma. Psammomatous meningiomas had meningothelial features. All tumors, except 1 COF, were positive for EMA. All of them expressed vimentin, and none showed cytokeratins. Staining for SMA and S-100 protein was variable. CD10 was positive in all cases except 2 meningiomas. CD34 and GFAP stained only 1 case of meningioma each.CONCLUSIONS:
The diagnosis of PSOF should rest on histologic features. An incorrect diagnosis of meningioma based on the expression of EMA should be avoided.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Seno Esfenoidal
/
Neoplasias Óseas
/
Neoplasias de los Senos Paranasales
/
Fibroma Osificante
/
Senos Etmoidales
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Asunto de la revista:
ODONTOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
España