[Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis].
Zhonghua Nan Ke Xue
; 12(5): 394-6, 400, 2006 May.
Article
en Zh
| MEDLINE
| ID: mdl-16755864
ABSTRACT
OBJECTIVE:
To study the expression of alpha-catenin in the rat testis after intra-testicular testosterone withdrawal induced by injection of testosterone undecanoate (TU).METHODS:
Ten adult male SD rats received vehicle (n = 5 ) or TU (19 mg/kg every 15 days, n = 5) for 130 days. Paraffin-embedded testicular sections were used for immunohistochemistry against a polyclonal anti-alpha-catenin antibody.RESULTS:
In the control, alpha-catenin was expressed in the acrosome of spermatids and the cytoplasm of Leydig cells and peritubular myoid cells. In the TU-treated rat testis, Leydig cells were atrophied and the expression of alpha-catenin was markedly decreased or absent, but there was no evident change in the immunostaining of spermatids or myoid cells.CONCLUSION:
Intra-testicular testosterone withdrawal-induced looser arrangement or sloughing of spermatogenic cells is not related to the adhesion molecule alpha-catenin. Alpha-catenin may be used as a cell identification marker for Leydig cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Testículo
/
Testosterona
/
Alfa Catenina
Límite:
Animals
Idioma:
Zh
Revista:
Zhonghua Nan Ke Xue
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2006
Tipo del documento:
Article
País de afiliación:
China