Neuromyelitis optica associated with myasthenia gravis: characteristic phenotype in Japanese population.
Eur J Neurol
; 13(6): 655-8, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16796591
ABSTRACT
We report two female patients with neuromyelitis optica (NMO, Devic's syndrome) following or coincidental with myasthenia gravis (MG). Their illnesses were characterized by subacute myelitis with optic neuritis, high serum levels of muscle acetylcholine receptor antibody, and autoimmune thyroid disease. Both patients fulfilled the clinical criteria of NMO, however, NMO-IgG, autoantibody against aquaporin-4 water channel, was absent from their sera. Both NMO and MG are relatively rare diseases. The considerable coincidence of these two disorders suggests that there is a subgroup of patients with NMO having a common immunological pathogenesis with MG.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenotipo
/
Neuromielitis Óptica
/
Miastenia Gravis
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Eur J Neurol
Asunto de la revista:
NEUROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón