Synthesis and biological evaluation of 10,11-methylenedioxy-14-azacamptothecin.
Org Lett
; 8(16): 3513-6, 2006 Aug 03.
Article
en En
| MEDLINE
| ID: mdl-16869648
ABSTRACT
[reaction see text] 10,11-Methylenedioxy-14-azacamptothecin, a potent analogue of the antitumor agent camptothecin (CPT), has been prepared via a key condensation between AB and DE ring precursors. The biological testing of this compound validated a strategy for modulation of the off-rate of camptothecin analogues from the topoisomerase-DNA-CPT ternary complex via structural modification.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Camptotecina
/
Inhibidores de Topoisomerasa I
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos
