The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt-Jakob disease.
Int J Geriatr Psychiatry
; 21(11): 1031-5, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16955430
ABSTRACT
BACKGROUND:
Dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD.METHODS:
Clinical data of 12 patients with autopsy-confirmed DLB who had been clinically suspected to suffer from CJD were analysed to investigate possible clinical features which led to misdiagnosis.RESULTS:
There was an association in time between administering neuroleptics and rapid clinical deterioration in 8 out of 9 patients.CONCLUSION:
It is suggested that the neuroleptic sensitivity in LBD fuelled the misdiagnosis of CJD in the presented series. Diagnostic confusion between CJD and DLB may have important clinical consequences and may lead to treatment restrictions.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antipsicóticos
/
Síndrome de Creutzfeldt-Jakob
/
Enfermedad por Cuerpos de Lewy
/
Errores Diagnósticos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Geriatr Psychiatry
Asunto de la revista:
GERIATRIA
/
PSIQUIATRIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Países Bajos