Establishment of a foreign antigen secretion system in mycobacteria.
Infect Immun
; 58(12): 4049-54, 1990 Dec.
Article
en En
| MEDLINE
| ID: mdl-1701418
ABSTRACT
In order to develop recombinant Mycobacterium bovis BCG into a useful multivaccine vehicle, we established a foreign antigen secretion system in mycobacteria in which an extracellular alpha antigen of Mycobacterium kansasii was utilized as a carrier. By using this system, a B-cell epitope (Glu-12-Leu-Asp-Arg-Trp-Glu-Lys-Ile-19) of human immunodeficiency virus type 1 p17gag, which was identified by a fusion protein-based method, has been successfully obtained from BCG along with the alpha antigen. This is the first report of expression and secretion of a foreign viral antigen from BCG. It is possible that the system can become a universal vaccination vehicle applicable to protection against various infectious diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Proteínas Virales
/
Vacunas Sintéticas
/
Antígenos VIH
/
Productos del Gen gag
/
Vectores Genéticos
/
Mycobacterium bovis
Idioma:
En
Revista:
Infect Immun
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón