Your browser doesn't support javascript.
loading
Local delivery of doxorubicin for malignant glioma by a biodegradable PLGA polymer sheet.
Manome, Yoshinobu; Kobayashi, Toshiaki; Mori, Mariko; Suzuki, Rie; Funamizu, Naotake; Akiyama, Nobutake; Inoue, Sachiko; Tabata, Yasuhiko; Watanabe, Michiko.
Afiliación
  • Manome Y; Department of Molecular Cell Biology, Institute of DNA Medicine, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan. manome@jikei.ac.jp
Anticancer Res ; 26(5A): 3317-26, 2006.
Article en En | MEDLINE | ID: mdl-17094447
ABSTRACT
Implantable, biocompatible and biodegradable devices bearing an anticancer drug can provide promising local therapy to patients with malignant disorders. With the aim of treating brain tumors, especially gliomas, a membranous sheet containing doxorubicin was produced by co-polymerization to poly(D,L-lactide-co-glycolide) (PLGA). When release of the drug from the sheet was measured, sustained release continued until day 34. The data contrasted with the burst release from material containing a higher proportion of the drug. In terms of biodegradability, a subcutaneous 3 x 3-mm tetragonal sheet was almost completely absorbed by day 80. When a glioma was implanted subcutaneously and the tumor nodule exposed to the sheet, the device inhibited tumor growth significantly. The sheet consisted of an amorphous structure with cavities estimated to have a diameter of 0.5 - 3 microm by electron microscopic observation. Since the sheet is implantable, biodegradable and has a sustained-drug release property, the device may play a role in the local therapy of brain tumors.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Polímeros / Doxorrubicina / Sistemas de Liberación de Medicamentos / Ácido Láctico / Glioma / Antibióticos Antineoplásicos Límite: Animals Idioma: En Revista: Anticancer Res Año: 2006 Tipo del documento: Article País de afiliación: Japón
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Polímeros / Doxorrubicina / Sistemas de Liberación de Medicamentos / Ácido Láctico / Glioma / Antibióticos Antineoplásicos Límite: Animals Idioma: En Revista: Anticancer Res Año: 2006 Tipo del documento: Article País de afiliación: Japón
...