A comparative review of charged particle microbeam facilities.
Radiat Prot Dosimetry
; 122(1-4): 285-91, 2006.
Article
en En
| MEDLINE
| ID: mdl-17132660
ABSTRACT
At the low doses (and low dose rates) relevant to environmental and occupational radiation exposure (0-50 mSv), which are of practical concern for radiation protection, very few cells in the human organism experience more than one traversal by densely ionising particles in their lifetime, the intervals between the tracks, if any, typically being months or years. The biological effects of exactly one particle are not well known and cannot be simulated in vitro by conventional broad-beam exposures, due to the random Poisson distribution of tracks. Charged particle microbeam facilities are a unique tool that allows targeting of single cells and analysis of the induced damage on a cell-by-cell basis. In the past few years, many charged particle microbeam facilities for radiobiology have come into operation or are under development worldwide. Different experimental designs have been adopted at various laboratories regarding the achievement of micrometre (or sub-micrometre) ion beam size, by mechanical collimation or focusing, particle detection, and cell recognition and positioning systems. The different approaches are reviewed and discussed in this paper.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aceleradores de Partículas
/
Radiometría
/
Separación Celular
/
Técnicas de Cultivo de Célula
/
Iones Pesados
Tipo de estudio:
Health_technology_assessment
Idioma:
En
Revista:
Radiat Prot Dosimetry
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia