Role of second trimester sonography in detecting trisomy 18: a review of 70 cases.
J Clin Ultrasound
; 35(2): 68-72, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17206726
ABSTRACT
PURPOSE:
To investigate the role of second-trimester sonographic examination in the prenatal diagnosis of trisomy 18.METHODS:
Out of 22,150 fetal chromosomal analyses performed between 1990 and 2004, 70 trisomy 18 fetuses were found. The sonographic findings of this aneuploidy were analyzed.RESULTS:
The average maternal age was 32.4 years; the average gestational age was 19.5 weeks. Major anomalies were seen in 61 (87.1%) of the 70 fetuses with trisomy 18; among these, cardiac anomalies were the most common (47.1%), with a 27.1% incidence of ventricular septal defects. Anomalies of the central nervous system were seen in 35.7% of cases; abnormal head shape was the most frequently detected anomaly in this group (12.9%). Fifty-six (80%) of the fetuses had at least 1 minor anomaly; of these, choroid plexus cyst was the most common (38.6%). Increased nuchal fold thickness was detected in 17.1% of cases.CONCLUSION:
The vast majority of trisomy 18 fetuses have sonographically detectable abnormalities in the second trimester. Both the 87.1% frequency of major anomalies and the 80% frequency of minor anomalies are substantially higher than multiple biochemical marker tests could achieve. It was also demonstrated that fetal echocardiography plays a pivotal role in the diagnosis of trisomy 18.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trisomía
/
Anomalías Múltiples
/
Cromosomas Humanos Par 18
/
Ultrasonografía Prenatal
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Clin Ultrasound
Año:
2007
Tipo del documento:
Article
País de afiliación:
Hungria