[The efficacy of oxynicotinic acid a nd its derivatives in respect of functional activity of hepatocytes during acute toxic hepatopathy].
Patol Fiziol Eksp Ter
; (4): 22-3, 2006.
Article
en Ru
| MEDLINE
| ID: mdl-17300085
ABSTRACT
Hepatoprotective activity of oxynicotinic acid and its derivatives XC-2, XC-2, XC-4, XC-9 in destructive processes in the liver induced by CCl4 injection has been studied. It was found in that injection of oxynicotinic acid derivatives in toxic lesion of the liver decreases cytolysis, cholestasis, hepatodepressive and mesenchymal-inflammatory syndromes. Membrane-stabilizing and antioxidant effects of oxynicotinic acid derivatives increase in the following sequence XC-1 --> XC-2, XC-3 --> XC-4, mexidol --> XC-9.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hepatocitos
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Niacina
/
Antioxidantes
Límite:
Animals
Idioma:
Ru
Revista:
Patol Fiziol Eksp Ter
Año:
2006
Tipo del documento:
Article