Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine.
J Vet Med A Physiol Pathol Clin Med
; 54(1): 48-50, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17359455
ABSTRACT
Ketamine is a short-acting dissociative anaesthetic for chemical restraint and surgical anaesthesia in domestic and non-domestic animals. The present study was designed to determine the pharmacokinetics of a single dose of ketamine (10 mg/kg) after intramuscular (i.m.) administration to young ostriches premedicated with romifidine. Ketamine was rapidly absorbed after i.m. administration. Maximal ketamine concentration (C(max)) of 2.93 +/- 0.61 microg/ml was reached at 12.5 +/- 2.50 min and thereafter ketamine concentrations decreased rapidly. The elimination half-life (t(1/2 z)) obtained was 62.37 +/- 17.37 min and mean residence time (MRT) was 77.33 +/- 19.12 min. The area under the curve (AUC) was 114.19 +/- 15.76 microg x min/ml.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Struthioniformes
/
Ketamina
/
Anestésicos Disociativos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Vet Med A Physiol Pathol Clin Med
Año:
2007
Tipo del documento:
Article
País de afiliación:
España