Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.
Drug Metab Rev
; 39(1): 159-234, 2007.
Article
en En
| MEDLINE
| ID: mdl-17364884
ABSTRACT
This review brings you up-to-date with the hepatocyte research on 1) in vitro-in vivo correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk using human hepatocytes and hepatocyte-like cell lines; 3) the function and regulation of hepatic transporters and models used to elucidate their role in drug clearance; 4) mechanisms and examples of idiosyncratic and intrinsic hepatotoxicity; and 5) alternative cell systems to primary human hepatocytes. We also report pharmaceutical perspectives of these topics and compare methods and interpretations for the drug development process.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Hepatocitos
/
Sistema Enzimático del Citocromo P-450
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Metab Rev
Año:
2007
Tipo del documento:
Article
País de afiliación:
Alemania