Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall.
Antimicrob Agents Chemother
; 51(6): 2249-52, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17371817
ABSTRACT
Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Streptococcus pneumoniae
/
Ceftriaxona
/
Pared Celular
/
Daptomicina
/
Meningitis Neumocócica
/
Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2007
Tipo del documento:
Article
País de afiliación:
Suiza