[Risk factors for structural chromosomal abnormality in > or = 2 miscarriages, as an instrument for selective karyotyping]. / Risicofactoren voor structurele chromosoomafwijking bij > or = 2 miskramen als instrument voor selectieve karyotypering.
Ned Tijdschr Geneeskd
; 151(15): 863-7, 2007 Apr 14.
Article
en Nl
| MEDLINE
| ID: mdl-17472118
ABSTRACT
OBJECTIVE:
To identify additional risk factors and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages.DESIGN:
Nested case-control study.METHOD:
In 6 centres for clinical genetics in the Netherlands, data were collected from couples referred for karyotyping after 2 2 miscarriages from 1992-2000. Factors influencing the probability of carrier status were examined. The corresponding probability of carrier status was calculated for the various combinations of these factors.RESULTS:
In total 279 carrier couples and 428 non-carrier couples were included. 4 independent factors influencing the probability of carrier status were identified a younger maternal age at the time of second miscarriage, a history of > or = 3 miscarriages, a history of > 2 miscarriages in a brother or sister of either partner, and a history of> 2 miscarriages in parents of either partner. The calculated probability of carrier status in couples referred for chromosome analysis after two or more miscarriages, varied between 0.5-10.2%. In 18% of couples included, the risk was found to be so low (< 2.2%), that in couples with comparable risk factors, it may not be necessary to perform karyotyping.CONCLUSION:
This study demonstrated that the probability of carrier status in couples with > or = 2 miscarriages is modified by additional factors. Selective chromosome analysis would result in a more effective referral policy and therefore decrease the number of chromosome analyses and lower the costs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aborto Habitual
/
Pruebas Genéticas
/
Aberraciones Cromosómicas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Año:
2007
Tipo del documento:
Article