Regional variations of cytochrome oxidase activity in the central auditory system of Relnrl-Orl (reeler) mutant mice.
Neurosci Res
; 58(4): 378-85, 2007 Aug.
Article
en En
| MEDLINE
| ID: mdl-17499872
ABSTRACT
Despite preserved cell differentiation, the Reln(rl-Orl) phenotype comprises laminar abnormalities of cell position in auditory cortex and dorsal cochlear nucleus. The metabolic consequences of the cell ectopias were determined by estimating cytochrome oxidase (CO) activity, a marker of neuronal activity. CO activity increased in the granular cell layer of dorsal cochlear nucleus, trapezoid body nucleus, intermediate lateral lemniscus, central and external inferior colliculus, and pyramidal cell layer of primary auditory cortex. On the contrary, CO activity decreased in the superficial molecular layer of dorsal cochlear nucleus as well as in the medioventral periolivary nucleus. These metabolic variations are discussed in terms of their possible relation to morphologic anomalies observed in the mutant.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Auditiva
/
Núcleo Coclear
/
Complejo IV de Transporte de Electrones
/
Ratones Mutantes Neurológicos
Límite:
Animals
Idioma:
En
Revista:
Neurosci Res
Asunto de la revista:
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Francia