Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine.

Joshua, Alummoottil V; Sharma, Sanjay K; Strelkov, Alicia; Scott, John R; Martin-Iverson, Mathew T; Abrams, Douglas N; Silverstone, Peter H; McEwan, Alexander J B

Joshua, Alummoottil V; Sharma, Sanjay K; Strelkov, Alicia; Scott, John R; Martin-Iverson, Mathew T; Abrams, Douglas N; Silverstone, Peter H; McEwan, Alexander J B.

Afiliación

Joshua AV; Department of Oncology, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2. alummott@cancerboard.ab.ca

Bioorg Med Chem Lett ; 17(14): 4066-9, 2007 Jul 15.

Article en En | MEDLINE | ID: mdl-17502140

ABSTRACT

ABSTRACT

8-Iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine Iozapine, a potential D(4)-receptor ligand was synthesized using oxidative iodo-destannylation reaction. The preliminary biodistribution studies of radioiodinated iozapine have shown that the compound is taken up in the brains of mice and rabbits.

Asunto(s)

Encéfalo/metabolismo; Clozapina/análogos & derivados; Animales; Clozapina/síntesis química; Clozapina/metabolismo; Clozapina/farmacocinética; Ratones; Conejos; Receptores de Dopamina D4/metabolismo; Distribución Tisular

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Clozapina Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2007 Tipo del documento: Article

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