Admixture estimates based on ABO, Rh and nine STRs in two Venezuelan regions.
Ann Hum Biol
; 34(1): 56-67, 2007.
Article
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| MEDLINE
| ID: mdl-17536755
ABSTRACT
BACKGROUND:
The Venezuelan population is the product of Native American, African and European admixture. Few admixture studies have been made in Venezuela using short tandem repeats (STRs).AIM:
The study estimated the contribution of each parental group in two Venezuelan regions the Northern-Central and the Central-Western Regions. SUBJECTS ANDMETHODS:
Frequencies for ABO and Rh were estimated by maximum likelihood, and by direct count for nine STRs, for 211 individuals. Admixture was estimated using Chakraborty's gene identity method. Neighbour-joining dendrograms were obtained with Nei's DS distance calculated between the two regions, the parental populations and other Venezuelan and Latin American populations. A principal component analysis (PCA) was also performed.RESULTS:
For the Northern-Central Region, the estimate of admixture was 37.7% for the European component, 37.7% for the African and 24.6% for the Native American. For the Central-Western region, the estimate of admixture was 58.5% for the European, 16.5% for the African and 25.0% for the Native American component.CONCLUSIONS:
(i) All systems were in Hardy-Weinberg equilibrium, except the Rh blood group of the Central-Western Region; (ii) the European contribution is high in both groups; (iii) in the dendrogram and PCA, the studied populations appear close to other admixed populations, and their relative position with regard to the three parental populations coincides with the admixture analysis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema del Grupo Sanguíneo Rh-Hr
/
Sistema del Grupo Sanguíneo ABO
/
Repeticiones de Microsatélite
/
Grupos Raciales
/
Genética de Población
Límite:
Humans
País/Región como asunto:
America do sul
/
Venezuela
Idioma:
En
Revista:
Ann Hum Biol
Año:
2007
Tipo del documento:
Article
País de afiliación:
Venezuela