Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2.
Bioorg Med Chem Lett
; 17(15): 4191-5, 2007 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-17540560
ABSTRACT
The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with microM-level cytotoxic activity in cell-based assays with prostate and colon cancer cell lines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinasa de la Caseína II
/
Inhibidores de Proteínas Quinasas
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos