Cellular localization of androgen and estrogen receptors in mouse-derived motoneuron hybrid cells and mouse facial motoneurons.
Dev Neurobiol
; 67(10): 1362-70, 2007 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-17638386
ABSTRACT
The ability of gonadal steroid hormones to augment axonal regeneration after peripheral nerve injury has been well established in rat and hamster motoneuron systems, and provides a foundation for the use of these agents as neurotherapeutics. With the advent of mouse genetics and the availability of transgenic and knockout mice, the use of mice in studies of neuroprotection is growing. It has recently been demonstrated that both androgens and estrogens rescue motoneurons (MN) from injury in mouse-derived motoneuron hybrid cells in vitro and mouse facial motoneurons (FMN) in vivo (Tetzlaff et al. [2006] J Mol Neurosci 2853-64). To elucidate the molecular mechanisms of these effects, the present study examined the cellular localization of androgen and estrogen receptors in mouse MN in vitro and in vivo. Immunoblotting and immunocytochemistry studies established the presence of androgen receptor (AR) and estrogen receptor alpha/beta in immortalized mouse motoneuron hybrid cells and AR and estrogen receptor alpha in mouse FMN.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormonas Esteroides Gonadales
/
Receptores Androgénicos
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Receptores de Estrógenos
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Neuronas Motoras
/
Regeneración Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Dev Neurobiol
Asunto de la revista:
BIOLOGIA
/
NEUROLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos