Catalysis of zinc transfer by D-penicillamine to secondary chelators.
J Med Chem
; 50(22): 5524-7, 2007 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-17918925
ABSTRACT
The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition. D-PEN is the first drug to inhibit a zinc protease by catalyzing metal removal, and the name "catalytic chelation" is proposed for this mechanism.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicilamina
/
Zinc
/
Quelantes
/
Ácido Edético
/
Carboxipeptidasas A
/
Ergotioneína
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Estados Unidos