Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats.
Arq Neuropsiquiatr
; 65(3B): 810-5, 2007 Sep.
Article
en En
| MEDLINE
| ID: mdl-17952286
ABSTRACT
OBJECTIVE:
To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats.METHOD:
20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion 10 under normothermia and 10 under mild hypothermia (32 masculine C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation.RESULTS:
Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433).CONCLUSION:
Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ataque Isquémico Transitorio
/
Hipotermia Inducida
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arq Neuropsiquiatr
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil