Immune mechanism facilitating clearance of Trypanosoma gambiense by IgG3 antibody from infected host.
Trop Med Parasitol
; 42(4): 394-8, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1796240
ABSTRACT
The aggregation of trypansomes, immune adherence to macrophage and protection against infection of Trypanosoma gambiense are associated with IgG3 antibody. IgG3-mediated clumping trypanosomes are readily dissociated by the aid of complement to become free. Dissociation of the clumped trypanosomes in the equivalence area released approximately fifty percent of previous bound surface antigens. These antigens were capable of binding again to new IgG3 antibody. Experiments indicated that complement deposition altered functionally bivalent IgG3 antibody in the immune complex into a univalent one. Such event in the presence of complement is of great advantage to the infected host in killing pathogens in vivo, as it allows more antibodies to attach to surface antigens and subsequently initiate complement activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Trypanosoma brucei gambiense
/
Tripanosomiasis Africana
/
Proteínas del Sistema Complemento
/
Inmunoglobulina G
/
Antígenos de Protozoos
Límite:
Animals
Idioma:
En
Revista:
Trop Med Parasitol
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón