The ACTN3 R577X polymorphism in East and West African athletes.
Med Sci Sports Exerc
; 39(11): 1985-8, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-17986906
ABSTRACT
PURPOSE:
To determine the frequency of the ACTN3 R577X polymorphism (functional R allele and nonfunctional X allele) in a variety of African populations and to examine its influence on the success of elite East African endurance runners and West African sprinters.METHODS:
The R577X polymorphism was genotyped in 198 Ethiopian controls and 76 elite Ethiopian endurance athletes, 158 Kenyan controls and 284 elite Kenyan endurance runners, and 60 Nigerian controls and 62 elite Nigerian power athletes. Statistical analyses were performed by exact tests of population differentiation, using Arlequin, version 3. Analyses were carried out using 1 x 10(6) Markov chain steps, and 1 x 10(5) dememorization steps.RESULTS:
The frequency of the X allele was extremely low among Kenyans and Nigerians (approximately 1% homozygosity) and higher in Ethiopians (approximately 11% homozygosity). The low baseline frequencies of the three populations tested mean that any associations with sprint performance would likely be obscured. In Ethiopians, where baseline levels of 577XX were about 11%, there was no increased frequency in the endurance athletes.CONCLUSION:
Our data suggest that alpha-actinin-3 deficiency is not a major influence on performance in African athletes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_financiamento_saude
Asunto principal:
Polimorfismo Genético
/
Deportes
/
Actinina
Tipo de estudio:
Health_economic_evaluation
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Med Sci Sports Exerc
Año:
2007
Tipo del documento:
Article
País de afiliación:
Australia