Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production.
Appl Radiat Isot
; 66(3): 295-302, 2008 Mar.
Article
en En
| MEDLINE
| ID: mdl-17996453
ABSTRACT
In this paper, radionuclidic impurities generated during the bombardment of [18 O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) were studied. In order to assess such impurities and the efficacy of purification methods through the different steps of the synthesis, samples of the target filters, purification columns, [18 O]water recovered after the synthesis, and the final solution was collected and their activities measured and analyzed by means of a gamma-ray spectrometry system. The data demonstrated that purification methods adopted for the synthesis provide the [18F]FDG radionuclidically pure, as requested by the EU Pharmacopeia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radiofármacos
/
Fluorodesoxiglucosa F18
Idioma:
En
Revista:
Appl Radiat Isot
Asunto de la revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Año:
2008
Tipo del documento:
Article
País de afiliación:
Italia