[Botulinum toxin type A does not affect spontaneous discharge but blocks sympathetic-sensory coupling in chronically compressed rat dorsal root ganglion neurons].
Nan Fang Yi Ke Da Xue Xue Bao
; 27(11): 1638-41, 2007 Nov.
Article
en Zh
| MEDLINE
| ID: mdl-18024278
ABSTRACT
OBJECTIVE:
To study the effect of botulinum toxin type A (BTXA) on spontaneous discharge and sympathetic- sensory coupling in chronically compressed dorsal root ganglion (DRG) neurons in rats.METHODS:
In chronically compressed rat DRG, spontaneous activities of the single fibers from DRG neurons were recorded and their changes observed after BTAX application on the damaged DGR. Sympathetic modulation of the spontaneous discharge from the compressed DRG neurons was observed by electric stimulation of the lumbar sympathetic trunk, and the changes in this effect were evaluated after intravenous BTXA injection in the rats.RESULTS:
Active spontaneous discharges were recorded in the injured DRG neurons, and 47 injured DRG neurons responded to Ca2+-free artificial cerebrospinal fluid but not to BTXA treatment. Sixty-four percent of the neurons in the injured DRG responded to sympathetic stimulation, and this response was blocked by intravenously injection of BTXA.CONCLUSION:
BTXA does not affect spontaneous activities of injured DRG neurons, but blocks sympathetic-sensory coupling in these neurons.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxinas Botulínicas Tipo A
/
Ganglios Espinales
/
Síndromes de Compresión Nerviosa
/
Neuronas
Límite:
Animals
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Año:
2007
Tipo del documento:
Article
País de afiliación:
China