Achieving positive protein balance in the immediate postoperative period in neonates undergoing abdominal surgery.
J Pediatr
; 152(1): 63-7, 2008 Jan.
Article
en En
| MEDLINE
| ID: mdl-18154902
ABSTRACT
OBJECTIVES:
To determine whether neonates undergoing major abdominal surgical procedures in the first day of life could achieve a positive protein balance without protein toxicity in the immediate perioperative period by using parenteral amino acids and fentanyl analgesia. STUDYDESIGN:
Newborns undergoing major surgery for gastroschisis in the first 24 hours of life (n = 13) were alternately allocated to immediate postoperative parenteral administration of 1.5 g/kg(-1)/day(-1) versus 2.5 g/kg(-1)/day(-1) amino acids. Protein balance was determined at 1.6 to 2.6 days postoperatively with both nitrogen balance and leucine stable isotope methodology. Statistical analyses were conducted with the unpaired t test and linear regression.RESULTS:
Protein balance was significantly different in the 2 groups with both nitrogen balance and leucine stable isotope methodology. There was no evidence of protein toxicity as determined with blood urea nitrogen, creatinine, and ammonia concentrations.CONCLUSIONS:
Neonates undergoing the metabolic stress of abdominal surgery shortly after birth are able to achieve a net positive protein balance with parenteral amino acid administration without evidence of protein intolerance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cuidados Posoperatorios
/
Proteínas en la Dieta
/
Fentanilo
/
Nutrición Parenteral Total
/
Abdomen
/
Aminoácidos
/
Analgésicos Opioides
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Pediatr
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos