Real-time polymerase chain reaction detection of Bordetella pertussis DNA in acellular pertussis vaccines.

Tatti, Kathleen M; Slade, Barbara; Patel, Manisha; Messonnier, Nancy; Jackson, Tiffany; Kirkland, Kathryn B; Talbot, Elizabeth A; Tondella, M Lucia

Tatti, Kathleen M; Slade, Barbara; Patel, Manisha; Messonnier, Nancy; Jackson, Tiffany; Kirkland, Kathryn B; Talbot, Elizabeth A; Tondella, M Lucia.

Afiliación

Tatti KM; Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Meningitis and Vaccine Preventable Diseases Branch, Atlanta, GA 30333, USA. ket2@cdc.gov

Pediatr Infect Dis J ; 27(1): 73-4, 2008 Jan.

Article en En | MEDLINE | ID: mdl-18162945

RESUMEN

Using 2 real-time polymerase chain reaction (PCR) assays for Bordetella pertussis, 2 of 5 acellular pertussis vaccines were found to contain B. pertussis DNA. Because residual DNA in vaccines can cause environmental contamination, the administration of acellular pertussis vaccines to patients should be physically separated from the collection of patients' specimens for testing of B. pertussis DNA by real-time PCR.

Asunto(s)

Bordetella pertussis/genética; ADN Bacteriano/análisis; Vacuna contra la Tos Ferina/química; Reacción en Cadena de la Polimerasa/métodos; Vacunas Acelulares/química; Humanos; Tos Ferina/diagnóstico

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bordetella pertussis / ADN Bacteriano / Vacuna contra la Tos Ferina / Reacción en Cadena de la Polimerasa / Vacunas Acelulares Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Pediatr Infect Dis J Asunto de la revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos

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