Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide.
Int Immunopharmacol
; 8(2): 312-8, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18182246
ABSTRACT
Angiotensin II (Ang II) plays important roles in the regulation of cardiovascular functions and diseases mainly via the type 1 (AT1) receptor. In contrast, recent studies have shown that the actions of Ang II via the type 2 (AT2) receptor are counter-regulatory to those mediated via the AT1 receptor. Using an animal model of hypertension, we have demonstrated that Ang II produces a vasodilator effect through the AT2 receptor via the bradykinin (BK)-dependent activation of endothelial nitric oxide (NO) synthase. In this review, we focus on the role of BK and NO in AT2-receptor-mediated vasodilation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasodilatación
/
Angiotensina II
/
Bradiquinina
/
Receptor de Angiotensina Tipo 2
/
Óxido Nítrico
Límite:
Animals
Idioma:
En
Revista:
Int Immunopharmacol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Japón