Hfe acts in hepatocytes to prevent hemochromatosis.
Cell Metab
; 7(2): 173-8, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18249176
ABSTRACT
Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron overload. In both humans and mice, type I HH is associated with mutations in the broadly expressed HFE/Hfe gene. To identify where Hfe acts to prevent HH, we generated mice with tissue-specific Hfe ablations. This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long-standing question in medicine and explaining earlier clinical observations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Hepatocitos
/
Hemocromatosis
/
Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2008
Tipo del documento:
Article
País de afiliación:
Alemania