[Percutaneous absorption of meloxicam patches in hairless mouse].
Yao Xue Xue Bao
; 42(12): 1320-2, 2007 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-18338648
Meloxicam concentration in skin was determined following topical administration of meloxicam patches in hairless mouse. Samples were analysized by HPLC coupled with microdialysis sampling technique, in which in vivo recovery of probe was characterized by the retrodialysis method. It was indicated that the in vivo recovery of the probe was 14.0%. The range of steady state concentration of meloxicam in dialysate was 24-50 ng x mL(-1), and that was 170-360 ng x mL(-1) in the hairless mouse skin. Steady state concentration of meloxicam was reached shortly after the application of meloxicam patches, which was maintained during the period of experiment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Absorción Cutánea
/
Tiazinas
/
Tiazoles
/
Inhibidores de la Ciclooxigenasa 2
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2007
Tipo del documento:
Article
País de afiliación:
China