Gender differences in cardiovascular tolerance to short radius centrifugation.
J Gravit Physiol
; 14(1): P15-9, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-18372686
ABSTRACT
In preparing for the NASA Artificial Gravity Pilot Study the planned centrifuge loading protocol was tested in 11 ambulatory subjects (6 men, 5 women). Each was subjected to a single 60 min trial with 2.5G of equivalent gravitational load feet and 1G at the level of the mediastinum. Amongst the men, 5/6 completed the trial successfully with no adverse sequelae. However, amongst the women, 4/5 tests were stopped early because of presyncope. Women are known to have a greater predisposition to syncope following orthostatic stress under normal tilt table conditions, during lower body negative pressure and following space flight. Amongst the factors which may have contributed to their lower tolerance to centrifugation are anthropometric factors, the vasoactive effects of sex hormones, catecholamine levels, ability to augment total peripheral resistance in response to orthostatic stress, and structural differences in cardiac anatomy and physiology. However, determining the true cause of this difference will require further investigation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síncope
/
Reposo en Cama
/
Sistema Cardiovascular
/
Centrifugación
/
Medidas contra la Ingravidez
/
Gravedad Alterada
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Gravit Physiol
Asunto de la revista:
FISIOLOGIA
Año:
2007
Tipo del documento:
Article
País de afiliación:
Reino Unido