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Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.
Jabbour, Elias; Kantarjian, Hagop; Jones, Dan; Breeden, Megan; Garcia-Manero, Guillermo; O'Brien, Susan; Ravandi, Farhad; Borthakur, Gautam; Cortes, Jorge.
Afiliación
  • Jabbour E; Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Blood ; 112(1): 53-5, 2008 Jul 01.
Article en En | MEDLINE | ID: mdl-18403620
ABSTRACT
Chronic myeloid leukemia (CML) with T315I mutation has been reported to have poor prognosis. We analyzed 27 patients with T315I, including 20 who developed T315I after imatinib failure (representing 11% of 186 patients with imatinib failure), and 7 of 23 who developed new mutations after second tyrosine kinase inhibitor (TKI). Median follow-up from mutation detection was 18 months. At the time of T315I detection, 10 were in chronic phase (CP), 9 in accelerated phase, and 8 in blast phase. Except for the lack of response to second TKIs (P = .002), there was no difference in patient characteristics and outcome between patients with T315I and those with other or no mutations. Patients in CP had a 2-year survival rate of 87%. Although the T315I mutation is resistant to currently available TKIs, survival of patients with T315I remains mostly dependent on the stage of the disease, with many CP patients having an indolent course.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Pirimidinas / Proteínas Tirosina Quinasas / Leucemia Mielógena Crónica BCR-ABL Positiva / Mutación Puntual / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Pirimidinas / Proteínas Tirosina Quinasas / Leucemia Mielógena Crónica BCR-ABL Positiva / Mutación Puntual / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Blood Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos
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