Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia.
Leuk Res
; 32(11): 1770-5, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-18417213
ABSTRACT
Acute megakaryocytic leukemia is a rare form of acute myelogenous leukemia and may occur either de novo or by transformation of a preexisting myelodysplastic or myeloproliferative process including blast crisis of chronic myeloid leukemia (CML). Megakaryocytic blast crisis as the presenting manifestation of CML is extremely rare. We describe such a patient with no prior hematologic disease who presented with acute megakaryoblastic leukemia and extramedullary involvement, in whom the leukemic cells carried the BCR-ABL1 translocation as part of a complex karyotype. Using targeted sequential fluorescence in situ hybridization (T-FISH) technique, we detected two copies of BCR-ABL1 fusion gene in the leukemic blasts while the neutrophils carried a single copy of BCR-ABL1 fusion gene, thereby proving the origin of the megakaryoblastic leukemia from a previously undiagnosed CML clone. Blast crisis as a presenting manifestation of CML is rare and detecting clonal evolution of acute leukemia by specialized cytogenetic techniques may have important diagnostic and therapeutic implications.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Megacariocitos
/
Leucemia Mielógena Crónica BCR-ABL Positiva
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Crisis Blástica
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Leucemia Megacarioblástica Aguda
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Proteínas de Fusión bcr-abl
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Leuk Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos