Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.
Bioorg Med Chem Lett
; 18(11): 3392-9, 2008 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-18462938
ABSTRACT
Replacement of the carboxylic acid group in a series of previously described methylene-linked pyrazole EP(1) receptor antagonists led to the discovery of amide, reversed amide and carbamate derivatives. Two compounds, 10a and 10b, were identified as brain penetrant compounds and both demonstrated efficacy in the CFA model of inflammatory pain.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Receptores de Prostaglandina E
/
Analgésicos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Reino Unido