[Diurnal fluctuations of protein contents and the pH dependence of beta2-microglobulin stability in urine].
Izv Akad Nauk Ser Biol
; (1): 46-52, 2008.
Article
en Ru
| MEDLINE
| ID: mdl-18491561
Diurnal fluctuations of protein excretion into urine and the effect of urinary pH on the urinary protein concentrations were studied in patients with various kidney diseases. The diurnal kinetics of gamma-immunoglobulin, transferrin, albumin, alpha1-microglobulin, gamma-immunoglobulin light chains, and the retinol-binding protein proved to positively correlate with the diurnal fluctuations of proteinuria and to negatively correlate with urinary pH. Diurnal changes in urinary beta2-microglobulin content did not correlate with those of any other protein. Oral bicarbonate intake alkalinized the urine, increased the urinary beta2-microglobulin content, and led to a direct correlation between beta2-microglobulin excretion and excretion of other low-molecular proteins. Thus, proteinuria, single protein excretion, and urinary pH displayed diurnal rhythmicity in the patients; beta2-microglobulin was unstable in acid urine and its urinary level depended on the urinary pH.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteinuria
/
Microglobulina beta-2
/
Ritmo Circadiano
Límite:
Humans
Idioma:
Ru
Revista:
Izv Akad Nauk Ser Biol
Asunto de la revista:
BIOLOGIA
Año:
2008
Tipo del documento:
Article