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Gene amplification is a poor prognostic factor in anaplastic oligodendrogliomas.
Idbaih, Ahmed; Crinière, Emmanuelle; Marie, Yannick; Rousseau, Audrey; Mokhtari, Karima; Kujas, Michèle; El Houfi, Younas; Carpentier, Catherine; Paris, Sophie; Boisselier, Blandine; Laigle-Donadey, Florence; Thillet, Joëlle; Sanson, Marc; Hoang-Xuan, Khê; Delattre, Jean-Yves.
Afiliación
  • Idbaih A; Institut National de la Santé et de la Recherche Médicale, U711, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France. ahmed.idbaih@gmail.com
Neuro Oncol ; 10(4): 540-7, 2008 Aug.
Article en En | MEDLINE | ID: mdl-18544654
Various gene amplifications have been observed in gliomas. Prognostic-genomic correlations testing simultaneously all these amplified genes have never been conducted in anaplastic oligodendrogliomas. A set of 38 genes that have been reported to be amplified in gliomas and investigated as the main targets of amplicons were studied in a series of 52 anaplastic oligodendrogliomas using bacterial artificial chromosome-array based comparative genomic hybridization and quantitative polymerase chain reaction. Among the 38 target genes, 15 were found to be amplified in at least one tumor. Overall, 27% of anaplastic oligodendrogliomas exhibited at least one gene amplification. The most frequently amplified genes were epidermal growth factor receptor (EGFR) and cyclin-dependent kinase 4/sarcoma amplified sequence (CDK4/SAS) in 17% and 8% of anaplastic oligodendrogliomas, respectively. Gene amplification and codeletion of chromosome arms 1p/19q were perfectly exclusive (p = 0.005). In uni- and multivariate analyses, gene amplification was a negative prognostic factor for progression-free survival and overall survival in anaplastic oligodendrogliomas, providing complementary information to the classic prognostic factors identified in anaplastic oligodendrogliomas (extent of surgery, KPS, and chromosome arms 1p/19q status).
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglioma / Neoplasias Encefálicas / Amplificación de Genes Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglioma / Neoplasias Encefálicas / Amplificación de Genes Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2008 Tipo del documento: Article País de afiliación: Francia
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