Effects of hypoxic preconditioning in antioxidant enzyme activities in hypoxic-ischemic brain damage in immature rats.
Turk Neurosurg
; 18(2): 165-71, 2008 Apr.
Article
en En
| MEDLINE
| ID: mdl-18597231
ABSTRACT
AIM:
HI (hypoxic-ischemic) brain injury is a major cause of neonatal mortality and longterm neurological morbidity. The aim of the present study was to investigate the effects of HPC (hypoxic preconditioning) on the oxidative-antioxidative status in the neonatal HI brain model. MATERIAL ANDMETHODS:
Fifty five 7-day-old rats were placed into; Control, HPC, HPC+HI insult, and HI insult groups. HPC, The HPC+HI insult groups were subjected to hypoxia (37 degrees C, 8%O2) and the control group to normoxia for 2.5 hrs. Twenty-four hours later, the rats in the HPC+HI insult and HI insult groups were exposed to cerebral HI produced by unilateral right common carotid artery (CCA) occlusion combined with 90 min hypoxia. Four hours after recovery, the malondialdehyde (MDA) level and the activities of superoxide dismutase (SOD), and glutathione peroxidase (GPx) were determined in the brain tissues of the rats.RESULTS:
The findings of the present study suggest increased lipid peroxidation and/or decreased antioxidant activity in the brain of the HI rats.CONCLUSION:
The beneficial effects of HPC might not be related to the alterations in the antioxidative activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_cardiovascular_diseases
/
6_cerebrovascular_disease
Asunto principal:
Precondicionamiento Isquémico
/
Hipoxia-Isquemia Encefálica
/
Antioxidantes
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Turk Neurosurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Turquía