Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients.
J Virol
; 82(18): 9283-7, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18614638
ABSTRACT
Among 17 HLA-A2-positive healthy adults, CD8+ T-cell responses against an HLA-A2-restricted matrix protein 1 (M1) epitope increased after immunization with trivalent inactivated influenza vaccine (TIV) in two individuals. The presence of M1 in TIV was confirmed by Western blotting. T-cell cytotoxicity assays showed that TIV is processed and the epitope is presented by antigen-presenting cells to an M1 epitope-specific CD8+ T-cell line for specific lysis. These data show that TIV, which is formulated to contain surface glycoproteins to induce serotype-specific antibody responses, also contains M1, capable of inducing subtype cross-reactive CD8+ T-cell responses in some vaccinees.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Vacunas contra la Influenza
/
Vacunas de Productos Inactivados
/
Proteínas de la Matriz Viral
/
Linfocitos T CD8-positivos
/
Gripe Humana
/
Subtipo H1N1 del Virus de la Influenza A
/
Subtipo H3N2 del Virus de la Influenza A
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos