Synthesis and antiviral activity of azoles obtained from carbohydrates.
Carbohydr Res
; 343(14): 2468-74, 2008 Sep 22.
Article
en En
| MEDLINE
| ID: mdl-18692179
ABSTRACT
Herein we describe the synthesis of 1,2,4-triazolyl-3-thione;1,3,4-oxadiazole, and imidazo[2,1-b]thiazole derivatives from carbohydrates. The antiviral activity of these compounds was tested against Dengue and Junin virus (the etiological agent of Argentine hemorrhagic fever). The 3-(p-bromobenzoyl)-5-(1,2-O-isopropylidene-3-O-methyl-alpha-d-xylofuranos-5-ulos-5-yl)imidazo[2,1-b]thiazole was able to inhibit the replication of both viruses in Vero cells at concentration significantly lower than the CC(50).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_dengue
Asunto principal:
Antivirales
/
Azoles
/
Carbohidratos
/
Virus Junin
/
Virus del Dengue
Límite:
Animals
Idioma:
En
Revista:
Carbohydr Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Argentina