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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Ferreira, Manuel A R; O'Donovan, Michael C; Meng, Yan A; Jones, Ian R; Ruderfer, Douglas M; Jones, Lisa; Fan, Jinbo; Kirov, George; Perlis, Roy H; Green, Elaine K; Smoller, Jordan W; Grozeva, Detelina; Stone, Jennifer; Nikolov, Ivan; Chambert, Kimberly; Hamshere, Marian L; Nimgaonkar, Vishwajit L; Moskvina, Valentina; Thase, Michael E; Caesar, Sian; Sachs, Gary S; Franklin, Jennifer; Gordon-Smith, Katherine; Ardlie, Kristin G; Gabriel, Stacey B; Fraser, Christine; Blumenstiel, Brendan; Defelice, Matthew; Breen, Gerome; Gill, Michael; Morris, Derek W; Elkin, Amanda; Muir, Walter J; McGhee, Kevin A; Williamson, Richard; MacIntyre, Donald J; MacLean, Alan W; St, Clair David; Robinson, Michelle; Van Beck, Margaret; Pereira, Ana C P; Kandaswamy, Radhika; McQuillin, Andrew; Collier, David A; Bass, Nicholas J; Young, Allan H; Lawrence, Jacob; Ferrier, I Nicol; Anjorin, Adebayo; Farmer, Anne.
Afiliación
  • Ferreira MA; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Nat Genet ; 40(9): 1056-8, 2008 Sep.
Article en En | MEDLINE | ID: mdl-18711365
ABSTRACT
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Ancirinas / Canales de Calcio Tipo L / Estudio de Asociación del Genoma Completo Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Ancirinas / Canales de Calcio Tipo L / Estudio de Asociación del Genoma Completo Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2008 Tipo del documento: Article País de afiliación: Estados Unidos