Astrocytes in glaucomatous optic neuropathy.
Prog Brain Res
; 173: 353-73, 2008.
Article
en En
| MEDLINE
| ID: mdl-18929121
ABSTRACT
Glaucoma, the second most prevalent cause of blindness worldwide, is a degenerative disease characterized by loss of vision due to loss of retinal ganglion cells. There is no cure for glaucoma, but early intervention with drugs and/or surgery may slow or halt loss of vision. Increased intraocular pressure (IOP), age, and genetic background are the leading risk factors for glaucoma. Our laboratory and other investigators have provided evidence that astrocytes are the cells responsible for many pathological changes in the glaucomatous optic nerve head (ONH). Over several years, in vivo and in vitro techniques characterized the changes in quiescent astrocytes that lead to the reactive phenotype in glaucoma. Reactive astrocytes alter the homeostasis and integrity of the neural and connective tissues in the ONH of human and experimental glaucoma in monkeys. During the transition of quiescent astrocytes to the reactive phenotype altered astrocyte homeostatic functions such as cell-cell communication, migration, growth factor pathway activation, and responses to oxidative stress may impact pathological changes in POAG. Our data also suggests that the creation of a non-supportive environment for the survival of RGC axons through remodeling of the ONH by reactive astrocytes leads to progression of glaucomatous optic neuropathy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Nervio Óptico
/
Glaucoma de Ángulo Abierto
/
Astrocitos
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Brain Res
Año:
2008
Tipo del documento:
Article
País de afiliación:
Estados Unidos