Genomic analysis and comparison of Bordetella pertussis isolates circulating in low and high vaccine coverage areas.
Microbes Infect
; 10(14-15): 1582-6, 2008.
Article
en En
| MEDLINE
| ID: mdl-18977453
ABSTRACT
The aim of this study was to analyze Bordetella pertussis isolates circulating, between 1991 and 1995, in Niakhar, Senegal area where the pertussis vaccination coverage was low and to compare them with those circulating in France, before and after introduction of generalized pertussis vaccination for toddlers in 1959. We carried out bacteriological analyses, typing, genotyping and DNA microarray analyses. We found that the isolates circulating in Senegal between 1991 and 1995 are part of the same Pulsed Field Gel Electrophoresis Group, express the same antigens and possess the same gene deletions than isolates circulating in France before the introduction of vaccination, but are different from those circulating in 1991-1995. We confirmed the influence of pertussis vaccination on circulating isolates and that isolates vary with the pertussis cycle.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
Problema de salud:
2_enfermedades_transmissibles
Asunto principal:
Bordetella pertussis
/
Tos Ferina
/
Genoma Bacteriano
Límite:
Humans
País/Región como asunto:
Africa
/
Europa
Idioma:
En
Revista:
Microbes Infect
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Año:
2008
Tipo del documento:
Article
País de afiliación:
Francia