Infection of SCID mice with lactate dehydrogenase-elevating virus stimulates B-cell activation.
Viral Immunol
; 4(1): 59-70, 1991.
Article
en En
| MEDLINE
| ID: mdl-1905935
ABSTRACT
Mice of the C.B-17 strain homozygous for the scid mutation (SCID mice) were infected with lactate dehydrogenase-elevating virus (LDV), and plasma samples obtained at intervals up to 42 days postinfection were analyzed for total immunoglobulins, anti-LDV antibodies, virus-specific immune complexes, and viremia levels. The mice responded to LDV infection with transient increases in total blood IgM, production of IgM-antigen complexes and IgM anti-LDV, as well as increased blood IgG2a. However, SCID mice failed to make a specific IgG2a anti-LDV immune response, and their blood LDV levels were elevated about 100-fold relative to those of control mice. The results suggest a role for IgG antibodies in the regulation of viremia and demonstrate a viral pathway of B-cell differentiation in SCID mice.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Viremia
/
Linfocitos B
/
Activación de Linfocitos
/
Virus Elevador de Lactato Deshidrogenasa
/
L-Lactato Deshidrogenasa
Límite:
Animals
Idioma:
En
Revista:
Viral Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
VIROLOGIA
Año:
1991
Tipo del documento:
Article