Serial passage of sheep scrapie inoculum in Suffolk sheep.
Vet Pathol
; 46(1): 39-44, 2009 Jan.
Article
en En
| MEDLINE
| ID: mdl-19112113
ABSTRACT
Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. Susceptibility to the disease is partly dependent upon the genetic makeup of the host. In a recent study, it was shown that sheep intracerebrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. In the present study, when this scrapie inoculum was further passaged for 3 successive generations, the survival time was reduced by approximately 8 months in scrapie-susceptible (QQ on prion protein gene [PRNP] at codon 171) Suffolk sheep. It is concluded that inoculum No. 13-7 appears to have been stabilized in susceptible (171 QQ) Suffolk sheep and may be considered a specific isolate of sheep scrapie agent in the USA and therefore that it can be used to evaluate other isolates of sheep scrapie in this country.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Scrapie
/
Priones
/
Pase Seriado
/
Predisposición Genética a la Enfermedad
Límite:
Animals
Idioma:
En
Revista:
Vet Pathol
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos