Baculovirus expression systems for recombinant protein production in insect cells.
Recent Pat Biotechnol
; 3(1): 46-54, 2009.
Article
en En
| MEDLINE
| ID: mdl-19149722
ABSTRACT
Baculoviruses are lethal pathogens of insects, predominantly of the order Lepidoptera. These viruses have a bi-phasic life cycle, which greatly facilitates their use for biotechnological applications. They were exploited initially as biocontrol agents, and then engineered as protein expression vectors. The baculovirus expression vector system (BEVS) is now widely used for recombinant protein production. More recently they have become a popular choice for development as gene delivery and expression vectors in mammalian cells. This article reviews some of the major developments and patents relating to baculoviruses since their initial use as an expression tool and investigates current technologies alleviating bottlenecks in recombinant gene expression in insect cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Recombinantes
/
Transfección
/
Ingeniería de Proteínas
/
Baculoviridae
/
Vectores Genéticos
/
Insectos
Límite:
Animals
Idioma:
En
Revista:
Recent Pat Biotechnol
Asunto de la revista:
BIOTECNOLOGIA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Reino Unido