Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats.
Chin J Physiol
; 51(5): 292-300, 2008 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-19175185
ABSTRACT
Dextromethorphan (DM), an antitussive agent, has been shown to have anti-inflammatory and immunomodulatory effects in vitro. Thus, the aim of this study was to evaluate the effects of LK-3, an analog of DM, on sepsis induced by intravenous (i.v.) administration of lipopolysaccharide (LPS; 10 mg/ kg) in anesthetized Wistar rats. Results demonstrated that post-treatment with LK-3 (4 mg/kg, i.v.) significantly attenuated the deleterious hemodynamic changes (e.g., hypotension and bradycardia) in rats treated with LPS. Meanwhile, LK-3 (4 mg/kg) significantly inhibited the elevation of plasma tumor necrosis factor-alpha, as well as values of glutamate-oxalacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) caused by LPS. The induction of inducible NO synthase and the overproduction of NO and superoxide anions by LPS were also reduced by post-treatment of LK-3. Moreover, infiltration of neutrophils into the lungs and liver of rats 8 h after treatment with LPS was also reduced by post-treatment with LK-3. In conclusion, the beneficial effects of LK-3 on LPS-induced sepsis resulted from its anti-inflammatory and antioxidant effects.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotoxemia
/
Dextrometorfano
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Chin J Physiol
Año:
2008
Tipo del documento:
Article
País de afiliación:
China